Method of treating lymphangioleiomyomatosis (lam)

Details Method of treating lymphangioleiomyomatosis (lam) Method of treating lymphangioleiomyomatosis (lam)

A - Human Necessities

61

K

A61K 31/65 (2006.01)

Patent

CA 2607726

The invention provides a method for the treatment of Lymphangioleiomyomatosis (LAM) in the human subject in need thereof. The method comprises administering to the subject an effective amount of doxycycline or a salt thereof. The invention further provides a method for monitoring the efficacy of treatment. Treatment efficacy is monitored by measuring MMP levels. Reduction in MMP levels indicates that the treatment is effective.

L'invention se rapporte à une méthode de traitement de la lymphangioléiomyomatose (LAM) chez un sujet humain nécessitant un tel traitement. Le procédé consiste à administrer au sujet une dose efficace de coxycycline ou d'un de ses sels. L'invention concerne également un procédé permettant de contrôler l'efficacité du traitement. On contrôle l'efficacité du traitement en mesurant les concentrations de métalloprotéase matricielle. Une diminution des concentrations de métalloprotéase matricielle indique que le traitement est efficace.

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