C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C12N 9/00 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2349618
The present invention describes polynucleotides and polypeptides associated with PPAR.alpha.-mediated pathways that are useful as therapeutic compositions in method for the treatment of peroxisomal disorders. These polynucleotides and polypeptides were identified through the use of differential gene expression analysis. In particular, the present invention discloses eleven novel gene fragments, and numerous single nucleotide polymorphisms, located in previously disclosed genes, all of which have been discovered to be associated with PPAR.alpha.-mediated pathways.
L'invention concerne des polynucléotides et polypeptides associés aux mécanismes d'action induits par PPAR-.alpha. et utiles en tant que compositions thérapeutiques, dans une méthode de traitement de troubles du peroxysome. On a identifié ces polynucléotides et polypeptides en utilisant une analyse d'expression différentielle de gènes. L'invention concerne notamment onze nouveaux fragments de gènes, ainsi que de nombreux polymorphismes d'un nucléotide, situés dans des gènes précédemment décrits, dont on a trouvé que tous étaient associés aux mécanismes d'action induits par PPAR-.alpha..
Curagen Corporation
Everitt Peter R.
LandOfFree
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