Slc7s as modifiers of the p53 pathway and methods of use

Details Slc7s as modifiers of the p53 pathway and methods of use Slc7s as modifiers of the p53 pathway and methods of use

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C12Q 1/02 (2006.01) C12Q 1/42 (2006.01) C12Q 1/48 (2006.01) C12Q 1/527 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2448282

Human SLC7 genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of SLC7 are provided.

L'invention concerne des gènes humains SLC7 identifiés comme étant des modulateurs de la voie p53 et, de ce fait, constituant des cibles thérapeutiques pour des troubles associés à une fonction défectueuse de p53. La présente invention concerne également des procédés permettant d'identifier des modulateurs de p53, lesquels procédés consistent à cribler des agents modulant l'activité des SLC7.

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