Substituted benzoylguanidines, a process for their...

Details Substituted benzoylguanidines, a process for their... Substituted benzoylguanidines, a process for their...

C - Chemistry, Metallurgy

07

C

C07C 279/22 (2006.01) A61K 31/165 (2006.01) A61K 31/275 (2006.01) A61K 31/415 (2006.01) A61K 31/435 (2006.01) A61K 49/00 (2006.01) C07C 317/32 (2006.01) C07C 323/44 (2006.01) C07D 213/58 (2006.01) C07D 215/14 (2006.01) C07D 217/16 (2006.01) C07D 233/64 (2006.01)

Patent

CA 2186580

Substituted benzoylguanidines, a process for their preparation, their use as medicament or diagnostic agent, and medicament comprising them Compounds of the formula I Image I in which the substituents have the meanings given in the description, and their pharmaceutically tolerated salts, are obtained by reaction with guanidine of a compound II Image II in which R(1) to R(5) have the meaning given and L is a leaving group which can easily be replaced nucleophilic- ally. Compounds I are outstanding cardiovascular therapeutics.

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