A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/50 (2006.01)
Patent
CA 2589137
The field of the invention is that of oral medicaments or pharmaceutical compositions, in particular of the type including one or more active principles. The aim of the invention is to provide an improved oral medicament to be administered in one or several daily doses and enabling the modified release of active principles (in particular of one active principle), whereby the prophylactic and therapeutic effectiveness of said medicament is improved. This aim is achieved by the oral multimicrocapsule galenic form according to the invention, in which the active principle release is controlled by a dual release trigger mechanism: "time-dependent trigger" and "pH-dependent trigger". Said medicament includes microcapsules providing the modified release of the active principle, each comprising a core containing the active principle and one or more swelling agents and at least one coating for the modified release of the active principle.
Le domaine de l'invention est celui des médicaments ou compositions pharmaceutiques oraux, plus particulièrement du type de celles comprenant un ou plusieurs principes actifs. Le but de l'invention est de fournir un médicament oral perfectionné administrable en une ou plusieurs prises quotidiennes, à libération modifiée de principe actif (en particulier un principe actif) permettant d'améliorer l'efficacité prophylactique et thérapeutique d'un tel médicament. Ce but est atteint par la forme galénique orale multimicrocapsulaire selon l'invention dans laquelle la libération du PA est régie par un à double mécanisme de déclenchement de la libération: "temps déclenchant" et "pH déclenchant". Ce médicament comprend des microcapsules à libération modifiée de principe actif comportant chacune un coeur comprenant le principe actif et un ou plusieurs agents gonflants et au moins un revêtement permettant la libération modifiée du principe actif.
Castan Catherine
Guimberteau Florence
Meyrueix Remi
Soula Gerard
Flamel Technologies
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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