C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/4427 (2006.01) A61P 7/02 (2006.01) C07B 43/00 (2006.01) C07K 5/065 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2368830
The present invention relates to prodrugs of general formula (I). The meaning of said formula is given in the description. Disclosed are the prodrugs of pharmaceutically active, heterocyclic amidines. In vivo compounds which are competitive inhibitors of trypsin-like serine proteases, especially thrombin, are produced from the amidines. The invention also relates to the production and use of the prodrugs as medicaments.
La présente invention concerne des promédicaments de formule générale (I) dont la signification est donnée dans la description de l'invention. Cette invention concerne les promédicaments d'amidines hétérocycliques, pharmaceutiquement actives, à partir desquelles des composés sont produits in vivo, lesdits composés constituant des inhibiteurs compétitifs des sérines protéases du type trypsine, notamment de la thrombine. De plus, l'invention concerne la production de ces promédicaments et leur utilisation en tant que médicaments.
Backfisch Gisela
Baucke Dorit
Delzer Jurgen
Hornberger Wilfried
Mack Helmut
Basf Aktiengesellschaft
Robic
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