C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/50 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01)
Patent
CA 2091874
Triazolopyridazine Compounds, Their Production and Use ABSTRACT OF THE DISCLOSURE Novel compound represented by the formula: Image [I] wherein R1 stands for H, an optionally substituted lower alkyl group or a halogen; R2 and R3 respectively stands for a hydrogen or an optionally substituted lower alkyl group, or R2 and R3 may, taken together with the adjacent -C=C- group, form a 5- to 7 membered ring; X stands for O, SO or SO2; Y stands for a group of the formula: Image (R4 and R5 respectively stand for H or an optionally substituted lower alkyl group) or a divalent group derived from an optionally substituted 3- to 7-membered homocyclic or heterocyclic ring; R6 and R7 each stands for H, an optionally substituted lower alkyl group, an optionally substituted cycloalkyl group or an optionally substituted aryl group, or R6 and R7 may, taken together with the adjacent N, form an optionally substituted N containing heterocyclic group; m stands for 0 to 4; n stands for 0 to 4, or a salt thereof, which has excellent anti-PAF activities anti-LTC4 activities and anti-ET-1 activities, and is of value as an antiasthmatic agent, and their production, intermediates and pharmasceutical compositions.
Ashida Yasuko
Kawano Yasuhiko
Miyake Akio
Fetherstonhaugh & Co.
Takeda Chemical Industries Ltd.
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