Methods and apparatus for intrapulmonary therapy and drug...

A - Human Necessities – 61 – M

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Details

A61M 25/088 (2006.01) A61M 16/04 (2006.01) A61M 11/06 (2006.01) A61M 16/14 (2006.01)

Patent

CA 2190196

An endotracheal catheter assembly and method for deep intrapulmonary, aerosol delivery of liquid drugs and other liquid therapeutic agents. The invention can deliver a bolus dose of liquid drugs into the lungs of a patient which is at least bioequivalent in terms of physiological effect to a similar drug dose delivered intravenously. The catheter assembly includes a first, gas-bearing tube and a second, liquid bearing tube, preferably concentrically nested within the gas-bearing tube. The tubes are inserted in an airway of the patient, preferably by threading the tubes into a lumen of an endotracheal tube, to position a terminal nozzle formed by distal tips of the tubes near a carina of the patient. At the nozzle, the lumen of the first tube has a comparative cross-sectional area relative to that of the second tube's lumen of between about 0.4:1.0 and 4.0:1Ø In operation, high velocity gas is forced from the first tube and impacts liquid expelled from the second tube at a high velocity gas/liquid interface, deforming the liquid into an aerosol and propelling it deep within the lungs of the patient.

Cathéter endotrachéal et méthode d'administration en aérosol de médicaments et d'autres agents thérapeutiques liquides profondément dans les poumons. L'invention permet d'administrer un embol de médicaments liquides dans les poumons d'un patient. La dose est au moins bioéquivalente en terme d'effet physiologique à une dose semblable de médicaments administrés par intraveineuse. Le cathéter comprend un premier tube à gaz et un second tube à liquide qui est, de préférence, niché de façon concentrique dans le tube à gaz. Les tubes sont insérés dans une voie aérienne du patient préférablement en les enfilant dans la lumière d'un tube endotrachéal pour placer une buse terminale, formée par les extrémités distales des tubes, près d'une carène du patient. Près de la buse, la lumière du premier tube présente une section transversale comparative par rapport à celle de la lumière du second tube entre 0,4/1,0 à 4,0/1,0 environ. Pendant l'utilisation de l'invention, on force à l'extérieur du premier tube un gaz à grande vitesse qui frappe le liquide expulsé du second tube à une interface gaz/liquide à grande vitesse, déformant ainsi le liquide en un aérosol et le poussant profondément dans les poumons du patient.

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