Use of vascular endothelial growth factor receptor...

Details Use of vascular endothelial growth factor receptor... Use of vascular endothelial growth factor receptor...

A - Human Necessities

61

K

A61K 31/502 (2006.01) A61B 5/145 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2653237

The invention relates to a method for screening patients for tumor burden and the use of VEGF-R inhibitors alone or in combination with chemotherapy for the treatment of gastrointestinal, genitourinary, lymphoid and pulmonary (small cell and non-small cell) cancer patients and patients with cancers of neural crest origin having high serum or plasma LDH5 levels.

L'invention concerne un procédé permettant de cribler des patients en vue de déterminer la charge tumorale, ainsi que l'utilisation d'inhibiteurs du récepteur du facteur de croissance endothélial vasculaire (VEGF-R), seuls ou combinés à une chimiothérapie, pour le traitement de patients souffrant de cancers gastro-intestinaux, urogénitaux, lymphoïdes et pulmonaires (à petites cellules ou à non-petites cellules) et de patients atteints de cancers trouvant leur origine dans la crête neurale, lesdits patients présentant des valeurs élevées de LDH5 sérique ou plasmatique.

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