Substituted diamino-1,3,5-triazine derivatives

Details Substituted diamino-1,3,5-triazine derivatives Substituted diamino-1,3,5-triazine derivatives

C - Chemistry, Metallurgy

07

D

C07D 251/16 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) C07D 251/18 (2006.01) C07D 403/06 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2216486

This invention concerns the compounds of formula (see fig. I) the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein R1 and R2 are each independently selected from hydrogen; hydroxy; amino; optionally substituted C1-6alkyl; C1-6alkyloxy; C1-6alkylcarbonyl; C1-6alkyloxycarbonyl; Ar1; mono- or di(C1-6alkyl)amino; mono- or di(C1-6alkyl)- aminocarbonyl; dihydro-2(3H)-furanone; or R1 and R2 taken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(C1-6alkyl)amino- C1-4alkylidene; R3 is hydrogen, Ar1, C1-6alkylcarbonyl, C1-6alkyl, C1-6alkyloxy-carbonyl, C1-6alkyl substituted with C1-6alkyloxycarbonyl; and R4, R5, R6, R7 and R8 are each independently selected from hydrogen, halo, C1-6alkyl, C1-6alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl or trihalomethyloxy; L is optionally substituted C1-10alkyl; C3-10alkenyl; C3-10alkynyl; C3-7cycloalkyl; Ar1 is optionally substituted phenyl; for the manufacture of a medicine for the treatment of subjects suffering from HIV (Human Immunodeficiency Virus) infection. It further relates to new compounds being a subgroup of the compounds of formula (I), their preparation and compositions comprising them.

L'invention porte sur des composés de formule (I) (voir fig. I), sur leurs sels d'addition avec des acides, acceptables en pharmacie, et sur leurs isomères stéréochimiques, où R1 et R2 sont chacun indépendamment l'un de l'autre un hydrogène ou un groupe hydroxy, amino, alkyle C1-6 avec substitution facultative, alkyloxy C1-6, alkylcarbonyle C1-6, alkyloxycarbonyle C1-6, Ar1, mono- ou di(alkyle C1-6)amino, mono- ou di(alkyle C1-6)- aminocarbonyle, dihydro-2(3H)-furanone; ou R1 et R2 peuvent former ensemble un groupe pyrrolidinyle, pipéridinyle, morpholinyle, azido ou mono- ou di(alkyle C1-6)amino-alkylidène C1-4; R3 est de l'hydrogène, un groupe Ar1, alkylcarbonyle C1-6, alkyle C1-6, alkyloxy-carbonyle C1-6, alkyle C1-6 avec substitution par un alkyloxycarbonyle C1-6; et R4, R5, R6, R7 et R8 sont chacun indépendamment l'un de l'autre un hydrogène, un halogène ou un groupe alkyle C1-6, alkyloxy C1-6, cyano, aminocarbonyle, nitro, amino, trihalométhyle ou trihalométhyloxy; L est un alkyle C1-10 avec substitution facultative, ou un groupe alcényle C3-10, alcynyle C3-10 ou cycloalkyle C3-7; Ar1 est un phényle avec substitution facultative; ces composés sont utiles dans la fabrication de médicaments pour les personnes victimes de l'infection par le VIH. L'invention porte aussi sur de nouveaux composés, faisant partie d'un sous-groupe des composés de formule (I), sur leur préparation et sur leur compositions.

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