Tumor necrosis factor receptor-associated factors

Details Tumor necrosis factor receptor-associated factors Tumor necrosis factor receptor-associated factors

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 14/715 (2006.01) C07K 16/18 (2006.01) C07K 16/46 (2006.01) C12N 5/12 (2006.01) C12N 15/62 (2006.01) C12N 15/81 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2190254

The invention concerns new tumor necro- sis factor receptor associated factors, designated TRAFs. The new factors are capable of specific association with the intracellular domain of the type 2 TNF receptor (TFN-R2) and CD40, and are involved in the mediation of TNF and CD40 ligand biological activities.

L'invention concerne de nouveaux facteurs associés au récepteur de facteur nécrose tumorale, désignés TRAFs. Les nouveaux facteurs sont capables d'association spécifique avec le domaine intracellulaire du récepteur TNF de type 2 (TNF-R2) et CD40, et sont impliqués dans la médiation d'activité biologique de ligand de CD40 et de TNF.

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