Tri-substituted phenyl derivatives as phosphodiesterase...

Details Tri-substituted phenyl derivatives as phosphodiesterase... Tri-substituted phenyl derivatives as phosphodiesterase...

C - Chemistry, Metallurgy

07

D

C07D 213/24 (2006.01) A61K 31/235 (2006.01) A61K 31/395 (2006.01) C07C 43/235 (2006.01) C07C 43/243 (2006.01) C07C 43/247 (2006.01) C07C 43/253 (2006.01) C07C 65/17 (2006.01) C07C 69/94 (2006.01) C07C 217/80 (2006.01) C07C 235/44 (2006.01) C07C 271/28 (2006.01) C07D 207/333 (2006.01) C07D 213/30 (2006.01) C07D 213/38 (2006.01) C07D 213/40 (2006.01) C07D 213/55 (2006.01) C07D 213/56 (2006.01) C07D 213/61 (2006.01) C07D 213/89 (2006.01) C07D 231/20 (2006.01) C07D 233/54 (2006.01) C07D 233/64 (2006.01) C07D 23

Patent

CA 2129039

Compounds of general formula (1) are described wherein Y is a halogen atom or a group -OR1, where R1 is an optionally substituted alkyl group; X is -O-, -S- or -N(R8)-, where R8 is a hydrogen atom or an alkyl group; R2 is an optionally substituted alkyl, alkenyl, cycloalkyl or cycloalkenyl group; R3 is a hydrogen or halogen atom or an -OR9 group, where R9 is a hydrogen atom or an optionally substituted alkyl, alkenyl, alkoxyalkyl, or alkanoyl group, or a formyl, carboxamido or thiocarboxamido group; R4 and R5, which may be the same or different, is each a group -(CH2)n Ar: where Ar is a monocyclic or bicyclic aryl group optionally containing one ore more heteroatoms selected from oxygen, sulphur or nitrogen atoms and n is zero or an integer 1, 2 or 3; R6 is a hydrogen atom or an optionally substituted alkyl group; R7 is a hydrogen atom or an optionally substituted alkyl group; and the salts, solvates, hydrates and N-oxides thereof. Compounds according to the invention are potent, selective and orally active PDE IV inhibitors and are useful in the prophylaxis and treatment of asthma and other diseases.

Affiliated with

Also associated with

Rating

Tri-substituted phenyl derivatives as phosphodiesterase... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Tri-substituted phenyl derivatives as phosphodiesterase..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Tri-substituted phenyl derivatives as phosphodiesterase... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1706454