Preparation of substituted alkenoic acids

Details Preparation of substituted alkenoic acids Preparation of substituted alkenoic acids

C - Chemistry, Metallurgy

07

D

C07D 413/00 (2006.01) C07D 263/16 (2006.01) C07D 263/34 (2006.01) C07D 413/10 (2006.01) C07F 7/10 (2006.01) C07F 7/22 (2006.01)

Patent

CA 2206469

This invention relates to a highly selective process for preparation of E-.omega.-phenyl-.omega.-(3-pyridyl)-.omega.-alkenoic acid derivatives bearing a carbamoyl substituted oxazolyl or oxazolinyl group on the phenyl ring which demonstrate utility for thromboxane receptor antagonism and/or thromboxane synthase inhibition, as well as to intermediates therefor.

L'invention concerne un procédé hautement sélectif pour la préparation de dérivés de l'acide E-oméga-phényl-oméga(3-pyridyl)-oméga-alcénoïque portant, sur le noyau phényle, un groupe oxazolyle ou oxazolinyle carbamoylé et qui sont utiles comme antagoniste du récepteur de la thromboxane et/ou inhibiteur de la thromboxane-synthase, ainsi que des intermédiaires de ces derniers.

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