C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 25/28 (2006.01) C07K 16/18 (2006.01) C12N 5/16 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2705582
Isolated antibodies have been characterized which show specific affinity to a repeating conformational epitope of a protofibril form of the human .beta.-amyloid peptide as compare to low molecular weight forms of .beta.-amyloid peptide. These isolated antibodies and related pharmaceutically effective compositions may be useful in the therapeutic and/or prophylactic treatment of Alzheimer's disease by effectively blocking the ability of the protofibril form of .beta.-amyloid peptide to form fibril forms linked with complications associated with Alzheimer's disease. The isolated antibodies of the present invention are also useful in various diagnostic assays and associated kits.
L'invention concerne des anticorps isolés caractérisés qui présentent une affinité spécifique pour un épitope conformationnel de répétition d'une forme de protofibrille du peptide b-amyloïde humain par comparaison à des formes à bas poids moléculaire de peptide b-amyloïde. Ces anticorps isolés et compositions pharmaceutiquement efficaces apparentées peuvent être utiles pour le traitement thérapeutique et/ou préventif de la maladie d'Alzheimer en bloquant efficacement la capacité de la forme de protofibrille du peptide b-amyloïde de produire des formes de fibrille liées aux complications associées à la maladie d'Alzheimer. Les anticorps isolés de la présente invention sont également utiles pour divers essais de diagnostic et kits associés.
Fukuyama Hidehiro
Ravetch Jeffrey
Moffat & Co.
The Rockefeller University
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