Substituted isoxazole derivatives and their use in...

Details Substituted isoxazole derivatives and their use in... Substituted isoxazole derivatives and their use in...

C - Chemistry, Metallurgy

07

D

C07D 413/04 (2006.01) A61K 31/422 (2006.01) A61K 31/4409 (2006.01) A61K 31/4439 (2006.01) A61P 29/00 (2006.01) C07D 213/00 (2006.01) C07D 261/00 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2495964

The invention relates to substituted isoxazole derivatives of formula (I), wherein the radicals R1, R2 and R3 have the meanings as cited in the description. The inventive compounds comprise an immunomodulatory action and/or an action that inhibits the release of cytokines and are thus suited for treating diseases associated with a disorder of the immune system, particularly immunologically mediated inflammatory diseases.

L'invention concerne des dérivés d'isoxazole substitués de formule (I) dans laquelle les restes R?1¿, R?2¿ et R?3¿ ont la signification indiquée dans la description. Les composés selon l'invention possèdent un effet immunomodulateur ou un effet inhibiteur sur la libération de cytokine et conviennent donc au traitement de maladies liées à une perturbation du système immunitaire, notamment de maladies inflammatoires à médiation immunologique.

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