C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/14 (2006.01) A61K 31/435 (2006.01)
Patent
CA 2223624
A compound of formula (I), wherein R1, R2, R3, R9 and R10 are as defined in the description. The compound of formula (I) and the pharmaceutically acceptable salts thereof are useful in inhibiting phosphodiesterase (PDE) Type IV and the production of tumor necrosis factor (TNF) and in the treatment of asthma, arthritis, bronchitis, chronic obstructive airways disease, psoriasis, allergic rhinitis, dermatitis and other inflammatory diseases characterized by phosphodiesterase (PDE) Type IV activity as well as AIDS, sepsis, septic shock and other diseases, such as cachexia, involving the production of TNF.
L'invention concerne un composé de la formule (I) dans laquelle R?1¿, R?2¿, R?3¿, R?9¿ et R?10¿ ont la signification donnée dans la description. Ledit composé et ses sels pharmaceutiquement acceptables peuvent être utilisés pour inhiber la phosphodiestérase (PDE) de type IV et la production du facteur de nécrose tumorale (TNF) et pour traiter l'asthme, l'arthrite, la bronchite, une maladie obstructive chronique des voies aériennes supérieures, le psoriasis, la rhinite allergique, la dermatite et d'autres maladies inflammatoires caractérisées par l'activité de la phosphodiestérase (PDE) de type IV, ainsi que le SIDA, la septicémie, un choc septique et d'autres maladies, telles que la cachéxie, impliquant la production du facteur de nécrose tumorale.
Cooper Kelvin
Duplantier Allen J.
Pfizer Inc.
Smart & Biggar
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