Recombinant pseudomonas exotoxin with increased activity

Details Recombinant pseudomonas exotoxin with increased activity Recombinant pseudomonas exotoxin with increased activity

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 47/48 (2006.01) C07K 14/21 (2006.01) C07K 14/495 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C12N 1/21 (2006.01) C12N 9/10 (2006.01) C12N 15/54 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2136724

2136724 9325690 PCTABScor01 This invention relates to the production and use of recombinant Pseudomonas-derived toxins modified to increase their toxicity and potency in therapy. More particularly, the invention relates to certain deletions in domain II of the amino acid sequence of Pseudomonas exotoxin the domain which relates to the toxin's natural proteolytic processing.

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