Methods of identifying and using hla binding compounds as...

C - Chemistry – Metallurgy – 07 – D

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C07D 239/72 (2006.01) A61K 31/18 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) C07D 215/16 (2006.01) C07D 217/00 (2006.01) C07D 217/10 (2006.01) C07D 217/22 (2006.01) C07D 239/92 (2006.01) C07D 401/14 (2006.01) C07D 417/14 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2330458

A novel method for identifying compounds which bind HLA molecules and which can be used as HLA agonists or antagonists is provided. These compounds are useful especially in the treatment of autoimmune diseases, transplantation, graft-vs-host disease, and more particularly multiple sclerosis.

L'invention concerne un nouveau procédé permettant d'identifier les composés qui se lient avec les molécules HLA et qui peuvent être utilisés comme agonistes ou antagonistes vis-à-vis du HLA. Ces composés sont utiles en particulier dans le traitement des maladies auto-immunes, dans le cadre des transplantations, ainsi que pour le traitement de la réaction du greffon contre l'hôte, et plus particulièrement pour le traitement de la sclérose en plaques.

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