Benzylbenzimidazolyl derivatives as kinase inhibitors

Details Benzylbenzimidazolyl derivatives as kinase inhibitors Benzylbenzimidazolyl derivatives as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 235/30 (2006.01) A61K 31/4184 (2006.01) C07D 401/14 (2006.01) C07D 405/06 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2538743

Novel benzyl-benzimidazolyl derivatives as inhibitors of tyrosine kinases, particularly TIE-2, VEGFR, PDGFR, FGFR and/or FLT/KDR, for the treatment of tumors, according to formula (I), wherein the radicals R1, R2, r and s are defined according to Claim (1).

La présente invention concerne de nouveaux dérivés de benzyl-benzimidazolyle qui servent d'inhibiteurs de tyrosine kinases, notamment TIE-2, VEGFR, PDGFR, FGFR et/ou FLT/KDR, permettant de traiter des tumeurs. Ces composés présentent la formule (I) dans laquelle les radicaux R?1¿, R?2¿, r et s sont tels que définis dans la revendication 1.

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