Metabolic-based methods for modulating gene expression

Details Metabolic-based methods for modulating gene expression Metabolic-based methods for modulating gene expression

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 48/00 (2006.01) C12N 15/85 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2597708

This invention provides methods for modulating cellular gene expression for genes operably linked to an NRSE element that is recognized by an NRSF transcriptional repressor, by changing the concentration of reduced nicotinamide adenine dinucleotide (NADH) in the cell.

L'invention concerne des méthodes destinées à moduler l'expression génétique cellulaire pour des gènes reliés fonctionnels à un élément NRSE reconnu par un répresseur transcriptionnel NRSF par modification de la concentration de nicotinamide adénine dinucléotide réduit (NADH) dans la cellule.

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