Methods of creating and screening dna-encoded libraries

C - Chemistry – Metallurgy – 40 – B

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C40B 50/10 (2006.01) C40B 50/16 (2006.01) C40B 70/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2752543

The present invention features a number of methods for identifying one or more compounds that bind to a biological target. The methods include synthesizing a library of compounds, wherein the compounds contain a functional moiety having one or more diversity positions. The functional moiety of the compounds is operatively linked to an initiator oligonucleotide that identifies the structure of the functional moiety.

L'invention concerne plusieurs méthodes d'identification d'au moins un composé qui se lie à une cible biologique. Ces méthodes consistent à synthétiser une bibliothèque de composés, ces composés contenant une fraction fonctionnelle présentant au moins une position de diversité. La fraction fonctionnelle des composés est liée fonctionnelle à un oligonucléotide initiateur qui identifie la structure de la fraction fonctionnelle.

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