In vivo activation of tumor-specific cytotoxic t cells

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 9/12 (2006.01) A61K 35/14 (2006.01) A61K 38/08 (2006.01) A61K 38/17 (2006.01) A61K 38/18 (2006.01) A61K 39/00 (2006.01) C07K 7/06 (2006.01) C07K 14/71 (2006.01) C07K 14/82 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 16/32 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01) C12N 5/16 (2006.01) C12Q 1/02 (2006.01) G01N 33/566 (2006.01) G01N 33/569 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2207736

The present invention relates to methods, compositions, and peptides useful in activating CTLs in vivo with specificity for particular antigenic peptides. The invention also discloses the use of activated CTLs in vivo for the diagnosis and treatment of a variety of disease conditions, and compositions appropriate for these uses. Diagnostic systems, components, and methods are also described herein.

Des procédés, compositions et peptides servent à activer in vivo des lymphocytes T cytotoxiques qui présentent une spécificité pour des peptides antigéniques donnés. On utilise in vivo ces lymphocytes T activés pour diagnostiquer et traiter diverses maladies et on décrit des compositions appropriées à ces utilisations. On décrit aussi des systèmes, éléments et procédés de diagnostic.

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