C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/0783 (2010.01) C12N 5/078 (2010.01) A61K 35/14 (2006.01) A61P 37/06 (2006.01)
Patent
CA 2706458
Disclosed in this specification is a process for producing ex vivo expanded CD4+CD25+ regulatory T cells. The process includes the steps of extracting a sample that includes peripheral blood mononuclear cells from a human donor. The extracted cells include a certain number of cells which are CD4+CD25+ regulatory T cells. The relative population of the CD4+CD25+ regulatory T cells is enhanced such that the Treg cells constitute the majority of the cells in the sample. Thereafter, the population of the enriched Treg cells, that may include third-party derived Treg cells, is expanded to produce a clinically meaningful population of cells for use in the treatment of GVHD.
La présente invention concerne un procédé de fabrication de cellules T régulatrices CD4+CD25+ dilatées ex vivo. Le procédé comprend les étapes consistant à extraire un échantillon qui comprend des cellules mononucléaires de sang périphériques prélevées sur un donneur humain. Les cellules extraites comprennent un certain nombre de cellules qui sont des cellules T régulatrices CD4+CD25. La population relative des cellules T régulatrices CD4+CD25+ est améliorée de manière à ce que les cellules Treg constituent la majorité des cellules dans l'échantillon. Ensuite, la population des cellules Treg enrichies, qui peut comprendre des cellules Treg dérivées d'un tiers, est dilatée pour produire une population significative d'un point de vue clinique de cellules destinées à être utilisées dans le traitement de la GVHD (graft versus host disease).
Cao Tinghua
Li Li
Cao Tinghua
Li Li
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Therakos Inc.
LandOfFree
Process for reducing effects of graft versus host disease... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process for reducing effects of graft versus host disease..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for reducing effects of graft versus host disease... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1709488