Single chain class i major histo-compatibility complexes,...

Details Single chain class i major histo-compatibility complexes,... Single chain class i major histo-compatibility complexes,...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 14/74 (2006.01) C12N 5/10 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2404489

Methods of generating a functional mammalian single chain MHC class I complex in prokaryotic expression systems and a functional human single chain MHC class I complex in eukaryotic or prokaryotic expression systems, which complexes are capable of presenting specific antigenic peptides restricted to specific CTL clones.

L'invention concerne des méthodes de production d'un complexe CMH de classe 1 monocaténaire fonctionnel mammifère dans des systèmes d'expression procaryotes et un complexe CMH de classe 1 monocaténaire fonctionnel humain dans des systèmes d'expression eucaryotes et procaryotes, lesquels complexes sont capables de présenter des peptides antigéniques spécifiques limités à des clones de lymphocytes T cytotoxiques (CTL) spécifiques.

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