Serum albumin binding moieties

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/02 (2006.01) A61K 38/04 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/14 (2006.01) A61K 38/38 (2006.01) A61K 38/55 (2006.01) C07K 1/00 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/00 (2006.01) C07K 14/765 (2006.01) C07K 17/00 (2006.01) C07K 17/06 (2006.01) C07K 17/10 (2006.01) C07K 17/14 (2006.01) C12N 15/00 (2006.01) G01N 33/68 (2006.01) G01N 33/96 (2006.01)

Patent

CA 2440582

Compositions comprising non-naturally occurring serum albumin binding moieties are described, together with methods of use thereof, e.g., for detecting or isolating serum albumin molecules in a solution, for blood circulation imaging, and for linking therapeutics or other molecules to albumin. Preferred serum albumin binding peptides having a high affinity for human serum albumin are particularly disclosed.

L'invention concerne des compositions comprenant des groupes de liaison d'albumine sérique d'origine non naturelle, ainsi que des procédés d'utilisation de ces compositions, p. ex. pour la détection ou l'isolement des molécules d'albumine sérique dans une solution, pour la visualisation de la circulation sanguine, et pour la liaison de produits thérapeutiques ou d'autres molécules avec l'albumine. L'invention concerne en particulier des peptides de liaison d'albumine sérique présentant une affinité élevée avec l'albumine sérique humaine.

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