Selective caspase inhibitors and uses thereof

Details Selective caspase inhibitors and uses thereof Selective caspase inhibitors and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61K 31/223 (2006.01) A61K 31/47 (2006.01) A61K 31/5375 (2006.01) A61K 31/662 (2006.01) A61K 38/00 (2006.01) C07C 237/12 (2006.01) C07C 237/20 (2006.01) C07C 317/48 (2006.01) C07D 215/14 (2006.01) C07D 295/26 (2006.01) C07F 9/40 (2006.01) C07K 5/08 (2006.01) C07K 5/10 (2006.01) C07K 14/81 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2724785

The present invention relates to compounds of Formula I, IA, II, HA, III, or IHA and their pharmaceutical uses. Particular aspects of the invention relate to the use of those compounds for the selective inhibition of one or more caspases. Also described are methods where the compounds of Formula I, IA, II, IIA, III, or IIIA are used in the prevention and/or treatment of various diseases and conditions in subjects, including caspase-mediated diseases such as sepsis, myocardial infarction, ischemic stroke, spinal cord injury (SCI), traumatic brain injury (TBI) and neurodegenerative disease (e.g. multiple sclerosis (MS) and Alzheimer's, Parkinson's, and Huntington's diseases).

La présente invention concerne des composés de formule I, IA, II, IIA, III ou IIIA, et leurs utilisations pharmaceutiques. Des aspects particuliers de linvention concernent lutilisation de ces composés pour linhibition sélective dune ou de plusieurs caspases. Linvention concerne également des procédés selon lesquels les composés de formule I, IA, II, IIA, III ou IIIA sont utilisés dans la prévention et/ou le traitement de diverses maladies et états chez des sujets, y compris les maladies médiées par des caspases telles que la sepsie, linfarctus du myocarde, laccident ischémique cérébral, le traumatisme médullaire (SCI), le traumatisme cérébral (TBI) et les maladies neurodégénératives (p. ex. la sclérose en plaques (MS) et les maladies dAlzheimer, de Parkinson et dHuntington).

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