Replication-defective recombinant adenovirus with mutated...

Details Replication-defective recombinant adenovirus with mutated... Replication-defective recombinant adenovirus with mutated...

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 39/235 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2332181

The present invention provides a recombinant adenovirus having a genome with a deficiency in the E1 region and a mutation in the MLP. The invention also provides stocks of such viruses and compositions including the inventive viruses. The invention also provides cell lines for propagating the recombinant adenoviruses.

L'invention concerne un adénovirus recombinant, dont le génome est défectueux dans la région E1 et présente une mutation au niveau du MLP; des stocks desdits virus; des compositions contenant lesdits virus; et des lignées cellulaires permettant de propager lesdits adénovirus recombinants.

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