Sulfonamide derivative metabotropic glutamate r4 ligands

Details Sulfonamide derivative metabotropic glutamate r4 ligands Sulfonamide derivative metabotropic glutamate r4 ligands

C - Chemistry, Metallurgy

07

D

C07D 213/81 (2006.01) A61K 49/00 (2006.01) A61K 51/00 (2006.01) C07D 241/24 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01) C07D 493/08 (2006.01) A61K 31/635 (2006.01)

Patent

CA 2741400

Disclosed are mGluR4 positive allosteric modulator ligands of general formula (I) and radiolabeled derivates, their use as therapeutic agents for the treatment of central nervous system disorders modulated by mGluR4 and as ligands for the label-ing and diagnostic imaging of mGluR4 in mammals.

L'invention porte sur des ligands modulateurs allostériques positifs au mGluR4 de la formule générale (I) et sur des dérivés radiomarqués, sur leur utilisation en tant qu'agents thérapeutiques pour le traitement de troubles du système nerveux central modulés par mGluR4 et en tant que ligands pour le marquage et l'imagerie de diagnostic de mGluR4 chez les mammifères.

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