Membrane for isolating virus from solution

B - Operations – Transporting – 01 – D

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B01D 69/12 (2006.01) A61L 2/00 (2006.01) A61L 2/02 (2006.01) B01D 61/14 (2006.01) B01D 67/00 (2006.01) B01D 69/02 (2006.01) B01D 71/34 (2006.01) C07K 1/34 (2006.01)

Patent

CA 2063548

A composite membrane and process utilizing the membrane which is capable of selectively removing particles such as viral panicles from a solution such as a protein solu- tion is provided. The membrane comprises a porous mem- brane substrate, a surface skin having ultrafiltration separa- tion properties and an intermediate porous zone between the substrate and the skin which intermediate zone has an aver- age pore size smaller than that of the substrate. The interme- diate zone is free of voids which break the skin and which di- realy fluid communicate with the substrate. The composite is capable of a log reduction value of at least 3 (99.9 % remo- val) of particles selectively from solution.

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