New use of cyclolignans and new cyclolignans

Details New use of cyclolignans and new cyclolignans New use of cyclolignans and new cyclolignans

C - Chemistry, Metallurgy

07

D

C07D 493/04 (2006.01) A61K 31/34 (2006.01) A61K 31/36 (2006.01) A61K 31/365 (2006.01) A61P 5/06 (2006.01) A61P 9/10 (2006.01) A61P 17/06 (2006.01) A61P 35/00 (2006.01) C07D 317/48 (2006.01) C07D 317/54 (2006.01) C07D 317/70 (2006.01)

Patent

CA 2455328

The invention refers to new compounds and the use thereof as well as the use of known cyclolignans having a trans configuration of the lactone ring as inhibitors of the insulin-like growth factor-1 receptor. Said compounds can be used for treatment of IGF-1R dependent diseases, especially cancer. Especially deoxypodophyllotoxin can be used for treatment of leukemia in humans.

L'invention concerne de nouveaux composés et leur utilisation, ainsi que l'utilisation de cyclolignans connus présentant une position trans du noyau de lactone comme inhibiteurs du récepteur du facteur-1 de croissance semblable à l'insuline. Lesdits composés peuvent servir dans le traitement de maladies dépendant d'IGF-1R, notamment les cancers. En particulier, on peut utiliser la déoxypodo-phyllotoxine dans le traitement de la leucémie chez les humains.

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