New esters of hydroxy-substituted nitrogen heterocycles as...

Details New esters of hydroxy-substituted nitrogen heterocycles as... New esters of hydroxy-substituted nitrogen heterocycles as...

C - Chemistry, Metallurgy

07

D

C07D 451/02 (2006.01) A61K 31/46 (2006.01) A61K 45/06 (2006.01) A61P 11/06 (2006.01)

Patent

CA 2482637

The invention relates to novel compounds of general formula 1: (see formula 1) wherein X- denotes an anion with a single negative charge, A and B denote -O, -S, -NH, -CH2, -CH=CH or-N(C1-C4-alkyl)-; R denotes hydrogen, hydroxy, -C1-C4-alkyl, -C1-C4-alkyloxy, -C1-C4-alkylene-halogen, -O-C1-C4-alkylene- halogen, -C1-C4-alkylene-OH, -CF3, CHF2, -C1-C4-alkylene-C1-C4- alkyloxy, -O-COC1-C4-alkyl, -O-COC1-C4-alkylene-halogen, -C1-C4-alkylene-C3-C6- cycloalkyl, -O-COCF3 or halogen; R1 and R2 denote -C1-C5-alkyl optionally substituted or R1 and R2 together denote a -C3-C5-alkylene-bridge; R3, R4, R3' and R4'denote hydrogen, C1-C4-alkyl, C1-C4-alkyloxy, hydroxy, -CF3, -CHF2, CN, NO2 or halogen; and R x and R x' denote hydrogen, C1-C4-alkyl, C1-C4-alkyloxy, hydroxy, -CF3, -CHF2, CN, NO2 or halogen or R x and R x' together denote a single bond or a bridging group selected from the bridges -O, -S, -NH, -CH2, -CH2-CH2-, -N(C1-C4-alkyl), -CH(C1-C4-alkyl)- and -C(C1-C4-alkyl)2, and the use thereof as a medicament.

La présente invention concerne de nouveaux composés de la formule générale (1) où X et les restes A, B, R, R1, R2, R3, R3', R4, R4', Rx et Rx', ont la signification donnée dans les revendications et la description. L'invention concerne également leur procédé de production et leur utilisation comme médicaments.

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