C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2062969
Human membrane cofactor protein (MCP), a protein involved in regulation of complement activity, has been purified to homogeneity. The cDNAs encoding six isoforms of this protein have been retreived and permit deduction of the complete amino acid sequences and the recombinant production of proteins with this activity. pharmaceutical compositions in which MCP is the active ingredient for use in treating autoimmune diseases, antibody preparations for diagnosis, and DNA probes are also disclosed.
On a purifié jusqu'à obtention d'une homogénéité une protéine de cofacteur de membrane (PCM) humaine, une protéine impliquée dans la régulation de l'activité du complément. Les ADN complémentaires codant 6 isoformes de cette protéine ont été extraits, et permettent la déduction des séquences d'acides aminés complètes ainsi que la production recombinée de protéines par cette activité. L'invention concerne également des compositions pharmaceutiques dans lesquelles la PCM est l'ingrédient actif, utilisé dans le traitement de maladies autoimmunes, des préparations d'anticorps de diagnostic, ainsi que des sondes d'ADN.
Battison Williams Dupuis
Washington University
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