Injectable liquid formulation of paracetamol

Details Injectable liquid formulation of paracetamol Injectable liquid formulation of paracetamol

A - Human Necessities

61

K

A61K 31/167 (2006.01) A61K 9/08 (2006.01)

Patent

CA 2517491

The invention relates to a novel injectable liquid formulation of paracetamol, comprising an aqueous solvent, a buffer agent with a pKa between 4.5 and 6.5, an isotonic agent and the dimer of paracetamol of formula (I), a method for preparation of said formulation and the use of said dimer for the stabilisation of a liquid paracetamol pharmaceutical formulation.

L'invention concerne une nouvelle formulation pharmaceutique liquide injectable de paracétamol qui contient du paracétamol, un solvant aqueux, un agent tamponnant de pKa compris entre 4,5 et 6,5, un agent isotonisant et du dimère de paracétamol de formule (I) suivante, ainsi qu'un procédé pour préparer cette formulation, et l'utilisation de ce dimère pour stabiliser une formulation pharmaceutique liquide de paracétamol.

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