C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 285/135 (2006.01) A61K 31/425 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 417/04 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 491/044 (2006.01) C07D 498/04 (2006.01)
Patent
CA 2078669
2078669 9114430 PCTABS00007 A compound of formula (I) or pharmaceutically acceptable salts thereof wherein R is hydrogen or lower alkyl; Y is (A'); X is O, S, NR6 or N; XY taken together is (B'); R2 is OR4, SR4, or NR4R5 represents a covalent bond connecting its adjacent carbonyl with X when X is N, thereby forming a cyclic imide of formula (II); R15 is hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl, aryl lower alkyl, heterocyclic or heterocyclic lower alkyl, wherein the heterocyclic group is an oxygen, nitrogen or sulfur containing heterocycle containing from 5 to 14 ring atoms or R15 represents a covalent bond connecting its adjacent carbinol with X when Y is N, thereby forming a cyclic diol of formula (III), M is -(CHR9)p, HC = C-(CHR9)q, -CH = CR9, (C') or (D'); Z is hydrogen or lower alkyl or a covalent bond; ring A is an alicyclic, aromatic ring or oxygen, nitrogen or sulfur containing heterocyclic or heteroaromatic ring, contains from 5 to 14 ring atoms and may be unsubstituted or substituted with at least one substituent selected from the group consisting of lower alkyl, aryl, aryl lower alkyl, carboxy, OH, carbolower alkoxy, formyl, lower alkanoyl, OH, SR3 or NR3R7; R3, R7 and R6 are independently hydrogen or lower alkyl; R4 and R5 are independently H, lower alkyl, aryl or aryl lower alkyl; each R9 can be the same or different and is H, lower alkyl, aryl, aryl lower alkyl, OR10, SR10 or NR10R11; each R10 and R11 can be the same or different and is H, lower alkyl, aryl, aryl lower alkyl, lower alkanoyl or aroyl; R14 is H or lower alkyl or R14 and Z taken together form a covalent bond; p is 0-6; q is 0-4; and n is 0 or 1.
Mcfadden Fincham
Research Corporation Technologies Inc.
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