C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 17/00 (2006.01) A61L 15/32 (2006.01) C07K 5/10 (2006.01) C07K 17/06 (2006.01) C07K 17/10 (2006.01) C08B 37/00 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/534 (2006.01) G01N 33/566 (2006.01) G01N 33/569 (2006.01) G01N 33/58 (2006.01) G01N 33/60 (2006.01) G01N 33/68 (2006.01) G01N 33/92 (2006.01)
Patent
CA 2444055
It is intended to provide novel lipopolysaccharide adsorbents (bacteriotoxin adsorbents) which can be easily synthesized and modified into various analogous structures and are usable in adsorbing various lipopolysaccharides and a method of screening the same. A method of screening a bacteriotoxin adsorbent characterized by performing a binding assay with a peptide library with the use of a lipid A radioisotope-labeled preparation wherein a radioisotope has been introduced into a phosphonoxyethyl derivative of biosynthetic precursor type lipid A or Escherichia coli type lipid A; and bacteriotoxin adsorbents comprising a specific peptide library which are found out by the above screening method.
Nouveaux adsorbants de lipopolysaccharides (adsorbants de bactériotoxines) qui peuvent être facilement synthétisés et modifiés pour obtenir diverses structures analogues et qui peuvent être utilisés pour l'adsorption de divers lipopolysaccharides, ainsi que procédé de criblage desdits adsorbants. Ledit procédé de criblage d'un adsorbant de bactériotoxines consiste à effectuer une analyse de liaison avec une bibliothèque peptidique à l'aide d'une préparation lipide A marquée par radio-isotope, le radio-isotope ayant été introduit dans un dérivé phosphonoxyéthyle d'un lipide A de type précurseur biosynthétique ou dans un lipide A de type Escherischia coli. La présente invention concerne également des adsorbants de bactériotoxines comportant une bibliothèque peptidique spécifique qui sont découverts grâce au procédé de criblage susmentionné.
Fukase Koichi
Nestler Hans Peter
Japan Science And Technology Corporation
Ridout & Maybee Llp
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