Novel carboxamides for use as xa inhibitors

Details Novel carboxamides for use as xa inhibitors Novel carboxamides for use as xa inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/4184 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) A61P 7/02 (2006.01) C07D 235/14 (2006.01) C07D 401/12 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2551788

The invention relates to the novel substituted carboxamides of general formula (I), wherein A, B and R1 to R5 are defined as in claim 1, the tautomers, enantiomers, diastereomers, mixtures and salts thereof, especially the physiologically salts thereof with inorganic or organic acids or bases, which have valuable properties. The inventive compounds have an antithrombotic effect and are factor Xa inhibitors.

La présente invention concerne de nouveaux carboxamides substitués de formule générale (I), dans laquelle A, B et R?1¿ à R?5¿ sont tels que définis dans la revendication 1, leurs tautomères, leurs énantiomères, leurs diastéréomères, leurs mélanges et leurs sels, en particulier leurs sels physiologiquement acceptables avec des bases ou acides organiques ou inorganiques, lesquels composés présentent de précieuses caractéristiques. Ces composés ont un effet antithrombotique et sont des inhibiteurs du facteur Xa.

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