A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/50 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2609618
The invention relates to pharmaceutical compositions of acetylsalicylic acid- based microcapsules to selectively inhibit the COX in the portal vein and/or in the liver to reduce the production of thromboxane. Further, the pharmaceutical composition minimizes COX inhibition in the systemic circulation to optimize the inhibition of platelet aggregation. Certain embodiments also address methods of prevention and/or treatment of these diseases, using these oral compositions such as enhancing the safety of antithrombotic treatments. Other embodiments contemplate oral pharmaceutical compositions that combine acetylsalicylic acid with anti-platelet aggregation drugs, without inducing gastric side effects.
L'invention concerne des compositions pharmaceutiques de microcapsules à base d'acide acétylsalicylique qui permettent d'inhiber sélectivement la COX dans la veine porte et/ou dans le foie afin de réduire la production de thromboxane. En outre, la composition pharmaceutique de l'invention minimise l'inhibition de la COX dans la circulation systémique afin d'optimiser l'inhibition de l'agrégation des plaquettes. Dans certains modes de réalisation, l'invention concerne des procédés de prévention et/ou traitement de maladies au moyen des compositions orales précitées qui améliorent la sécurité des traitements antithrombotiques. D'autres modes de réalisation concernent des compositions pharmaceutiques orales qui combinent l'acide acétylsalicylique et des médicaments destinés à empêcher l'agrégation des plaquettes, sans provoquer d'effets secondaires gastriques.
Guimberteau Florence
Soula Gerard
Flamel Technologies
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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