Treatment of vascular graft implants with g-csf

Details Treatment of vascular graft implants with g-csf Treatment of vascular graft implants with g-csf

A - Human Necessities

61

K

A61K 38/19 (2006.01) A61K 38/18 (2006.01)

Patent

CA 2304095

This invention provides methods for enhancing the endothelialization of synthetic vascular grafts by administering to a graft recipient an agent that mobilizes bone marrow-derived CD34+ cells into the bloodstream, that enhances the adherence to graft surfaces of blood-borne endothelial progenitors, or that stimulates the multiplication of endothelial progenitors that have adhered to the graft surfaces.

La présente invention concerne un procédé d'amélioration de l'endothélisation de greffes vasculaires synthétiques en administrant, à un récipient de greffe, un agent qui mobilise des cellules CD34?+¿ dérivées de moelle osseuse dans la circulation sanguine. Cet agent améliore l'adhérence des progéniteurs endothéliaux hématogènes aux surfaces de greffe et stimule la multiplication des progéniteurs endothéliaux qui ont adhérés aux surfaces de greffe.

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