Methods, systems, compositions and dosage forms for...

C - Chemistry – Metallurgy – 12 – N

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C12N 5/076 (2010.01) A61K 31/661 (2006.01) A61K 35/52 (2006.01) A61P 15/08 (2006.01) C12Q 1/02 (2006.01) G01N 33/48 (2006.01) G01N 33/543 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2717000

Methods and systems are provided for diagnosing male infertility relating to inadequate production of phosphatidic acid and are complementary to the routine tests, assessing sperm count, motility, viability, head morphology, and white blood cell count. Additional therapeutic methods, compositions and dosage forms are provided for treating male infertility that is related to inadequate production of phosphatidic acid. Such therapeutic approaches involve the use of phosphatidic acid or at least one of its precursors in the sperm intracellular signaling pathway.

La présente invention concerne des procédés et des systèmes pour diagnostiquer linfertilité masculine liée à une production insuffisante dacide phosphatidique qui sont complémentaires des essais de routine, de lévaluation du nombre, de la motilité, de la viabilité, de la morphologie de tête des spermatozoïdes et de la numération leucocytaire. La présente invention concerne en outre dautres procédés, compositions et formes pharmaceutiques thérapeutiques pour traiter linfertilité masculine qui est liée à une production insuffisante dacide phosphatidique. De telles approches thérapeutiques mettent en uvre lutilisation dacide phosphatidique ou au moins un de ses précurseurs dans la voie de signalisation intracellulaire des spermatozoïdes.

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