Live attenuated vaccine against porcine pleuropneumonia

Details Live attenuated vaccine against porcine pleuropneumonia Live attenuated vaccine against porcine pleuropneumonia

A - Human Necessities

61

K

A61K 39/102 (2006.01) C07K 14/285 (2006.01) C12N 1/36 (2006.01)

Patent

CA 2505869

The present invention provides a method for obtaining an immunogenic, non haemolytic strain of Actinobacillus pleuropneumoniae which is modified, at least in a segment of the apxIA gene and optionally in a segment of the apxIIA gene that codes a transmembrane domain of the Apx haemolytic and cytolytic exotoxins. It comprises also the strains, and the attenuated live vaccine against porcine pleuropneumonia obtained therewith.

L'invention concerne un procédé permettant d'obtenir une souche immunogène, non hémolytique de Actinobacillus pleuropneumoniae qui est modifiée, au moins dans un segment du gène apxIA et éventuellement dans un segment du gène apxIIA qui code un domaine transmembranaire des exotoxines hémolytiques et cytolytiques Apx. Elle concerne également les souches, et le vaccin atténué vivant contre la pleuropneumonie du porc obtenu avec ces souches.

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