Irak-4: compositions and methods of use

Details Irak-4: compositions and methods of use Irak-4: compositions and methods of use

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A01K 67/027 (2006.01) A61K 38/44 (2006.01) C12N 5/10 (2006.01) C12N 9/12 (2006.01) C12N 15/85 (2006.01) C12Q 1/48 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2397481

The present invention provides nucleic acids and polypeptides for IRAK-4, a novel member of the IRAK family of protein kinases. Members of the IRAK family are indispensable signal transducer for members of the IL-1R/Toll family of transmembrane receptors, including IL-1 receptors, IL-18 receptors and LPS receptors. IRAK-4 sequences from human and mouse are provided, as are methods for identifying compounds useful in the treatment or prevention of inflammatory diseases.

L'invention concerne des acides nucléiques et des polypeptides pour IRAK-4, nouveau membre de la famille IRAK de protéines kinases. Les membres de la famille IRAK sont un transducteur de signal indispensable pour des membres de récepteurs transmembranaires IL-1R/Toll, y compris les récepteurs IL-1, IL-18 et LPS. L'invention concerne les séquences IRAK-4 de l'homme et de la souris ainsi que les procédés permettant d'identifier des composés utiles pour le traitement ou la prévention de maladies inflammatoires.

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