Antibodies that specifically bind to reg iv

Details Antibodies that specifically bind to reg iv Antibodies that specifically bind to reg iv

A - Human Necessities

61

K

A61K 39/395 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2490280

The present invention relates to antibodies and related molecules that specifically bind to Reg IV. Such antibodies have uses, for example, in the prevention and treatment of gastrointestinal tract cancers, inflammatory bowel disorders, and diabetes. The invention also relates to nucleic acid molecules encoding anti-Reg IV antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially gastrointestinal tract cancers, inflammatory bowel disorders, and diabetes, comprising administering to an animal, preferably a human, an effective amount of one or more antibodies or fragments or variants thereof, or related molecules, that specifically bind to Reg IV.

La présente invention se rapporte à des anticorps et à des molécules associées qui se lient spécifiquement à Reg IV (gène de régénération). Ces anticorps sont utiles, par exemple, dans la prévention et le traitement de cancers du tube digestif, des affections intestinales inflammatoires, et du diabète. L'invention se rapporte également à des molécules d'acide nucléique codant des anticorps anti Reg IV, des vecteurs et des cellules hôtes contenant ces acides nucléiques, et leurs procédés de production. L'invention se rapporte à des méthodes et à des compositions de prévention, de détection, de diagnostic, de traitement et d'amélioration d'une maladie ou d'une affection, notamment des cancers du tube digestif, des affections intestinales inflammatoires, et du diabète. Ces méthodes consistent à administrer à un animal, mais de préférence à un être humain, une quantité efficace d'un ou de plusieurs anticorps ou fragments ou leurs variantes, ou des molécules associées, qui se lient spécifiquement à Reg IV.

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