Methods and compositions for the diagnosis and treatment of...

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) C07K 14/47 (2006.01) C12Q 1/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2238829

Methods for the treatment of squamous cell carcinoma using a p53-expressing viral vector are disclosed. In particular embodiments, the vector is a replication-deficient adenovirus. In addition, there are provided methods for examining the development and treatment of microscopic residual disease in the context of post-surgical environments and in body cavities.

L'invention concerne des méthodes de traitement de carcinomes spino-cellulaire, dans lesquelles on utilise un vecteur viral exprimant p53. Dans des formes d'exécution spéciales, le vecteur est un adénovirus incapable de se multiplier. En outre, l'invention concerne des méthodes permettant de suivre l'évolution et le traitement de maladies microscopiques résiduelles après une intervention chirurgicale, ainsi que dans des cavités du corps.

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