Estrogenic extracts of scuttelaria barbata d. don of the...

Details Estrogenic extracts of scuttelaria barbata d. don of the... Estrogenic extracts of scuttelaria barbata d. don of the...

A - Human Necessities

61

K

A61K 36/539 (2006.01) A61P 15/12 (2006.01) A61P 19/10 (2006.01) A61P 35/00 (2006.01) B01D 15/26 (2006.01)

Patent

CA 2698747

Extracts of various species of the Moraceae family have estrogenic properties. For example, aqueous and ethanolic extracts of Scuttelaria barbata D. Don of the Labiatae Family species possess estrogenic properties in both ER.alpha.+ and ER.beta.+ cells. These estrogenic effects include estrogen response element (ERE) stimulation as well as tumor necrosis factor (TNF) repression. Methods are provided for treating climacteric symptoms, breast and/or uterine cancer, and osteoporosis.

L'invention concerne des extraits de diverses espèces de la famille Moraceae ayant des propriétés oestrogéniques. Par exemple, des extraits aqueux et éthanoliques de Scuttelaria barbata D. Don des espèces de la famille Labiatae possèdent des propriétés oestrogéniques à la fois dans les cellules ERa+ et ERß+. Ces effets opestrogéniques sont la stimulation de l'élément de réponse aux oestrogènes (ERE), ainsi que la répression du facteur de nécrose tumorale (TNF). L'invention concerne également des méthodes de traitement des symptômes du climatère, du cancer du sein et/ou de l'utérus et de l'ostéoporose.

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