Treatment of inflammation, demyelination and neuronal/axonal...

Details Treatment of inflammation, demyelination and neuronal/axonal... Treatment of inflammation, demyelination and neuronal/axonal...

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2683127

The invention relates to compositions and methods for treating or preventing inflammation in a mammal comprising mucosal administration of an effective amount of an E-selectin polypeptide. Such compositions and methods are useful for treating or preventing a variety of conditions and diseases, including, for example, stroke, vascular dementia and autoimmune or inflammatory demyelinating diseases such as multiple sclerosis.

L'invention concerne des compositions et des procédés pour le traitement ou la prévention de l'inflammation chez un mammifère, comprenant l'administration mucosale d'une quantité efficace d'un polypeptide E-sélectine. De telles compositions et de tels procédés sont utiles pour le traitement ou la prévention d'une variété de troubles et de maladies, notamment, par exemple, l'accident cérébrovasculaire, la démence vasculaire et les maladies démyélinisantes auto-immunes ou inflammatoires telles que la sclérose en plaques.

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