Human regulator of g-protein signaling - (hrgs)

Details Human regulator of g-protein signaling - (hrgs) Human regulator of g-protein signaling - (hrgs)

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2269665

The present invention provides a human regulator of G-protein signaling (HRGS) and polynucleotides which identify and encode HRGS. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HRGS and a method for producing HRGS. The invention also provides for agonists, antibodies, or antagonists specifically binding HRGS, and their use, in the prevention and treatment of diseases associated with expression of HRGS. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HRGS for the treatment of diseases associated with the expression of HRGS. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HRGS.

La présente invention concerne un régulateur humain de signalisation de protéines G (HRGS) et des polynucléotides identifiant et codant le HRGS. Elle concerne également des vecteurs d'expression mis au point par génie génétique, des cellules hôtes comprenant les séquences d'acide nucléique codant le HRGS et un procédé de production du HRGS. De plus, l'invention concerne des agonistes, des anticorps ou des antagonistes liant spécifiquement le HRGS, ainsi que leur utilisation dans la prévention et le traitement de maladies liées à l'expression du HRGS. L'invention porte en outre sur l'utilisation de molécules antisens à des polynucléotides codant le HRGS pour le traitement des maladies liées à l'expression du HGRS. Elle porte aussi sur des techniques de diagnostic utilisant le polynucléotide, des fragments ou le complément de celui-ci, ainsi que sur des anticorps liant spécifiquement le HRGS.

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