Recombinant birnavirus vaccine

Details Recombinant birnavirus vaccine Recombinant birnavirus vaccine

C - Chemistry, Metallurgy

12

N

C12N 7/01 (2006.01) A61K 39/12 (2006.01) A61K 39/15 (2006.01) C12N 7/00 (2006.01) C12N 7/04 (2006.01) C12N 15/33 (2006.01) C12N 15/40 (2006.01) C12N 15/86 (2006.01) G01N 33/50 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2238659

The present invention provides a birnavirus mutant which is suited as vaccine candidate in eradication control programmes. The mutant is not able to produce a native VP5 protein, and this feature can be used as a marker to distinguish between animals vaccinated with the VP5 mutant or infected with a naturally-occurring birnavirus.

La présente invention porte sur un mutant du birnavirus qui peut être utilisé comme candidat- vaccin dans le cadre de programmes d'éradication de maladies. Le mutant est incapable de produire une protéine native du gène VP5, et cette caractéristique peut être utilisée comme marqueur afin de distinguer les animaux vaccinés avec le mutant du gène VP5 des animaux infectés par un birnavirus naturel.

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