Use of lacritin in promoting ocular cell survival

Details Use of lacritin in promoting ocular cell survival Use of lacritin in promoting ocular cell survival

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61P 27/02 (2006.01)

Patent

CA 2566607

The present invention relates to the use of lacritin, and fragments, derivatives, and homologs thereof, and nucleic acid sequences encoding that protein. The invention relates to the use of lacritin as a growth factor human corneal epithelial cells and other select epithelial cells. The invention also relates to the use of lacritin in promoting ocular cell survival in response to an insult or injury, in protecting against ocular inflammation, and in promoting ocular wound repair.

L'invention concerne l'utilisation de la lacritine, de fragments, de dérivés et d'homologues de celle-ci, ainsi que des séquences nucléotidiques codant pour cette protéine. Elle porte aussi sur l'utilisation de la lacritine en tant que facteur de croissance pour les cellules épithéliales de la cornée et d'autres cellules épithéliales choisies. L'invention se rapporte également à l'utilisation de la lacritine dans la promotion de la survie de cellules oculaires en réponse à une agression ou à une lésion, dans la protection contre l'inflammation oculaire et dans la promotion de la cicatrisation oculaire.

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