A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 39/205 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2607569
Compositions and methods are provided for screening and identifying compounds which modulate signaling of toll-like receptor 4 (TLR4) pathway via CD 14 and a ligand. Methods are provided for treatment of various disease states such as inflammation or autoimmune disease in mammalian subjects by modulating toll- like receptor 4 (TLR4) pathway signaling via CD 14 and a ligand. Transgenic non-human animals and methods for developing transgenic non-human animals are provided wherein the transgenic non-human animals comprise a loss-of-function mutation in the CD 14 gene.
La présente invention concerne des compositions et des procédés de recherche systématique et d'identification de composés modulant la signalisation du chemin du récepteur 4 de type Toll (TLR4) via le CD14 et un ligand. L'invention concerne également le traitement de divers états pathologiques tels que l'inflammation ou les maladies auto-immunes chez des sujets mammifères par modulation de la signalisation du chemin du récepteur 4 de type Toll (TLR4) via le CD14 et un ligand. L'invention concerne enfin des animaux transgéniques non-humains et des procédés de développement d'animaux transgéniques non humains grâce auxquels les animaux transgéniques non-humains présentent dans le gène CD14 une mutation à perte de fonction.
Beutler Bruce
Jiang Zhengfan
Smart & Biggar
The Scripps Research Institute
LandOfFree
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