C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07H 21/00 (2006.01) C07K 14/705 (2006.01) C12N 1/15 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2314379
The present invention relates to novel Dendriac and novel Brainiac-3 polypeptides which are members of the Brainiac family. In particular, isolated nucleic acid molecules are provided encoding the human Dendriac and Brainiac-3 polypeptides. Dendriac and Brainiac-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Dendriac and Brainiac-3 activities. Also provided are diagnostic methods for detecting immune and nervous system-related disorders and therapeutic methods for treating immune and nervous system-related disorders.
La présente invention concerne de nouveaux polypeptides Dendriac et Brainiac-3 appartenant à la famille des Brainiac. L'invention concerne, en particulier, des molécules d'acide nucléique isolées codant les polypeptides Dendriac et Brainiac-3 humains. L'invention concerne également les polypeptides Dendriac et Brainiac-3, ainsi que des vecteurs, des cellules hôtes et des procédés de recombinaison permettant de produire ces derniers. L'invention se rapporte en outre à des procédés de criblage permettant d'identifier des agonistes et des antagonistes des activités des Dendriac et des Brainiac-3. L'invention se rapporte enfin à des méthodes diagnostiques permettant de détecter des affections du système immunitaire et du système nerveux et à des méthodes thérapeutiques permettant de traiter des affections du système immunitaire et du système nerveux.
Ebner Reinhard
Endress Gregory A.
Florence Kimberly A.
Rosen Craig A.
Ruben Steven M.
Human Genome Sciences Inc.
Mbm Intellectual Property Law Llp
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